autoimmunity

Noun

autoimmunity (countable and uncountable, plural autoimmunities)

1. The condition where one's immune system attacks one's own tissues, i.e., an autoimmune disorder.
   • This can be demonstrated in NOD mice in which a point mutation in the autoimmune regulator (Aire) gene results in the reduced expression of P0 in the thymus and a concomitant increase of P0 specific T cells in the periphery. 107 Similarly, autoimmunity is shifted towards the peripheral nerve in...2015 February 12, Emily K Mathey et al., “Chronic inflammatory demyelinating polyradiculoneuropathy: from pathology to phenotype”, in Journal of Neurology, Neurosurgery, and Psychiatry, volume 86...
   • Iberdomide, a cereblon modulator promoting degradation of the transcription factors Ikaros and Aiolos, which affect leukocyte development and autoimmunity, is being evaluated for the treatment of systemic lupus erythematosus (SLE).2022 March 17, Joan T. Merrill, Victoria P. Werth, Richard Furie et al., “Phase 2 Trial of Iberdomide in Systemic Lupus Erythematosus”, in The New England Journal of Medicine, volume 386, number 11...