isoform

Noun

isoform (plural isoforms)

1. Any of several different forms of the same protein, arising from either single nucleotide polymorphisms, differential splicing of mRNA, or post-translational modifications (e.g. sulfation, glycosylation, etc.)
   • Intriguingly, the rat C1b isoform of the calcitonin receptor (CTR) (see Section VI-B) has very little interaction with the thyroidally derived form of calcitonin.1997, Louis V. Avioli, Metabolic Bone Disease and Clinically Related Disorders, page 98
   • This can be demonstrated in NOD mice in which a point mutation in the autoimmune regulator (Aire) gene results in the reduced expression of P0 in the thymus and a concomitant increase of P0 specific T cells in the periphery. 107 Similarly, autoimmunity is shifted towards the peripheral nerve in...2015 February 12, Emily K Mathey et al., “Chronic inflammatory demyelinating polyradiculoneuropathy: from pathology to phenotype”, in Journal of Neurology, Neurosurgery, and Psychiatry, volume 86...