Word.ws English Dictionary

Lipinski's rule of five

Lipinski's rule of five proper noun: a rule of thumb stating that a chemical compound is likely to be an orally active drug in humans unless it violates more than one of these criteria: (i) no more than 5 hydrogen bond donors (the total number of nitrogen–hydrogen and oxygen–hydrogen bonds); (ii) no more than 10 hydrogen bond acceptors (all nitrogen or oxygen atoms); (iii) a molecular mass less than 500 daltons; (iv) an octanol-water partition coefficient (log P) that does not exceed 5.

Proper noun

Lipinski's rule of five

  1. A rule of thumb stating that a chemical compound is likely to be an orally active drug in humans unless it violates more than one of these criteria: (i) no more than 5 hydrogen bond donors (the total number of nitrogen–hydrogen and oxygen–hydrogen bonds); (ii) no more than 10 hydrogen bond acceptors (all nitrogen or oxygen atoms); (iii) a molecular mass less than 500 daltons; (iv) an octanol-water partition coefficient (log P) that does not exceed 5.

Synonyms of Lipinski's rule of five

Origin of Lipinski's rule of five

The rule was formulated by Christopher A. Lipinski in 1997. Five refers to the multiples of five that occur in all of the criteria.

Questions about Lipinski's rule of five

What does Lipinski's rule of five mean?
Lipinski's rule of five means a rule of thumb stating that a chemical compound is likely to be an orally active drug in humans unless it violates more than one of these criteria: (i) no more than 5 hydrogen bond donors (the total number of nitrogen–hydrogen and oxygen–hydrogen bonds); (ii) no more than 10 hydrogen bond acceptors (all nitrogen or oxygen atoms); (iii) a molecular mass less than 500 daltons; (iv) an octanol-water partition coefficient (log P) that does not exceed 5.
What part of speech is Lipinski's rule of five?
Lipinski's rule of five is a proper noun.

Words near Lipinski's rule of five in the dictionary

  1. Lipilip
  2. lipin
  3. lipinic
  4. lipins
  5. Lipinski
  6. Lipinski's rule of five
  7. Lipinskis
  8. lipiodol
  9. Lipitor
  10. Lipizza
  11. Lipizzan

Source and license

Adapted from Wiktionary: Lipinski's rule of five (page history and authors). Text available under the Creative Commons Attribution-ShareAlike 4.0 license. Word.ws reformatted the entry and added links. Wiktionary data of 2026-09-02.

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