macroenzymes

Noun

macroenzyme (plural macroenzymes)

1. An enzyme of macromolecular size due to unusual biopolymerization or immune complexing, such as when a normal enzyme is protein-bound, typically by immunoglobulins (antibodies); macroenzymes by themselves are not always pathophysiologic or pathogenic, but their occurrence is increased in certain diseases (their formation is encouraged by some pathogenetic processes).
   • Macroenzymes are serum enzymes that have a higher molecular mass than the corresponding enzyme normally found in serum under physiologic or pathophysiologic conditions. Although no evidence convincingly indicates that macroenzymes cause disease or necessitate treatment, some patients with...1993, Galasso PJ, Litin SC, O'Brien JF, “The macroenzymes: a clinical review”, in Mayo Clinic Proceedings, volume 68, number 4, →DOI, →PMID, pages 349–354