macrothrombocytopaenia

Noun

macrothrombocytopenia (countable and uncountable, plural macrothrombocytopenias)

1. A form of thrombocytopenia characterised by unusually large platelets.
   • Absence or dysfunction of GPIb-V-IX results in the Bernard-Soulier Syndrome, a bleeding disorder characterised not only by impaired platelet adhesion, but also by macrothrombocytopenia, due to a disturbed link between the GPIb-V-IX complex and the underlying cytoskeleton during platelet and/or MK...2015 July 16, “Artificial MiRNA Knockdown of Platelet Glycoprotein lbα: A Tool for Platelet Gene Silencing”, in PLOS ONE, →DOI

   Synonyms:

   giant platelet disorder