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paroxysmal nocturnal hemoglobinuria

paroxysmal nocturnal hemoglobinuria noun: a rare, acquired blood disorder in which a mutation in the PIGA gene causes red blood cells to lack protective surface proteins, making them vulnerable to complement-mediated destruction, leading to hemolysis, anemia, dark urine, and increased risk of blood clots.

paroxysmal nocturnal hemoglobinuria: a rare, acquired blood disorder in which a mutation in the PIGA gene causes red blood cells to lack...
Image: Prof. Osaro Erhabor, CC BY-SA 4.0, via Wikimedia Commons

Noun

paroxysmal nocturnal hemoglobinuria (uncountable, abbreviation PNH)

  1. A rare, acquired blood disorder in which a mutation in the PIGA gene causes red blood cells to lack protective surface proteins, making them vulnerable to complement-mediated destruction, leading to hemolysis, anemia, dark urine, and increased risk of blood clots.

Synonyms of paroxysmal nocturnal hemoglobinuria

Forms of paroxysmal nocturnal hemoglobinuria

abbreviationPNH
alternative UKparoxysmal nocturnal haemoglobinuria

Questions about paroxysmal nocturnal hemoglobinuria

What does paroxysmal nocturnal hemoglobinuria mean?
Paroxysmal nocturnal hemoglobinuria means a rare, acquired blood disorder in which a mutation in the PIGA gene causes red blood cells to lack protective surface proteins, making them vulnerable to complement-mediated destruction, leading to hemolysis, anemia, dark urine, and increased risk of blood clots.
What part of speech is paroxysmal nocturnal hemoglobinuria?
Paroxysmal nocturnal hemoglobinuria is a noun.

Words near paroxysmal nocturnal hemoglobinuria in the dictionary

  1. paroxysmal
  2. paroxysmal atrial tachycardia
  3. paroxysmal atrial tachycardias
  4. paroxysmal cold hemoglobinuria
  5. paroxysmal nocturnal haemoglobinuria
  6. paroxysmal nocturnal hemoglobinuria
  7. paroxysmal trepidant abasia
  8. paroxysmally
  9. paroxysmic
  10. paroxysms
  11. paroxysome

Source and license

Adapted from Wiktionary: paroxysmal nocturnal hemoglobinuria (page history and authors). Text available under the Creative Commons Attribution-ShareAlike 4.0 license. Word.ws reformatted the entry and added links. Wiktionary data of 2026-09-02.

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