Word.ws English Dictionary

pegRNA

pegRNA noun: a specialized guide RNA used in prime editing, comprising a single guide RNA (sgRNA) extended with a primer binding site (PBS) and a reverse transcription template (RTT) that encodes the desired genetic edit.

Noun

pegRNA (countable and uncountable, plural pegRNAs)

  1. (molecular biology) A specialized guide RNA used in prime editing, comprising a single guide RNA (sgRNA) extended with a primer binding site (PBS) and a reverse transcription template (RTT) that encodes the desired genetic edit.
    • Prime editors (PEs), initially represented by PE1, employed a reverse transcriptase (RT) fused to an RNA-programmable nickase (Cas9n) and a prime editing guide RNA (pegRNA) to directly copy genetic information from the extension on the pegRNA into the target genomic locus.2020, Narendra Tuteja, Renu Tuteja, Nishat Passricha, Shabnam Saifi, editors, Advancement in Crop Improvement Techniques, Woodhead Publishing, page 165
    • Briefly, upon Cas9-mediated nicking of the target site, the extended tail of the pegRNA hybridizes with the free 3' end, which serves as an RT template and encodes the desired edit to be incorporated into the genome.2022, Marcello Maresca, Sumit Deswal, editors, Genome Editing in Drug Discovery, John Wiley & Sons, page 332

Forms of pegRNA

pluralpegRNAs

Origin of pegRNA

Acronym of prime editing guide RNA.

Questions about pegRNA

What does pegRNA mean?
PegRNA means a specialized guide RNA used in prime editing, comprising a single guide RNA (sgRNA) extended with a primer binding site (PBS) and a reverse transcription template (RTT) that encodes the desired genetic edit.
What part of speech is pegRNA?
PegRNA is a noun.
What is the plural of pegRNA?
The plural of pegRNA is pegRNAs.

Words near pegRNA in the dictionary

  1. pegomancy
  2. pegos
  3. PEGOT
  4. Pegram
  5. Pegrams
  6. pegRNA
  7. pegRNAs
  8. pegroots
  9. Pegrum
  10. pegs
  11. pegs away

Source and license

Adapted from Wiktionary: pegRNA (page history and authors). Text available under the Creative Commons Attribution-ShareAlike 4.0 license. Word.ws reformatted the entry and added links. Wiktionary data of 2026-09-02.

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Cite this entry: “pegRNA.” Word.ws, https://word.ws/pegrna. Based on Wiktionary, CC BY-SA 4.0.