triple negative

Adjective

triple-negative (not comparable)

1. Of a breast cancer: characterized by the lack of expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2).
   • Multiple BrCa [breast cancer] microarray datasets (Sorlie et al PNAS 2003; van't Veer et al, Nature 2002; Sotiriou et al, PNAS 2003) suggest that 90% of BBT [basal breast tumor] are ER-negative, PR-negative, and HER-2 nonamplified (Perou C, unpublished). Thus, this “triple negative” phenotype may...2004 July 15, L. A. Carey, C. M. Perou, L. G. Dressler, et al., “Race and the poor prognosis basal breast tumor (BBT) phenotype in the population-based Carolina Breast Cancer Study (CBCS)”, Meeting...