Word.ws English Dictionary

VEXAS

VEXAS noun: an autoimmune disease that causes inflammation in the body and mostly affects men.

Noun

VEXAS (uncountable)

  1. An autoimmune disease that causes inflammation in the body and mostly affects men.
    • Using a genotype-driven approach, we identified a disorder that connects seemingly unrelated adult-onset inflammatory syndromes. We named this genetic disorder the VEXAS syndrome, which is caused by myeloid-restricted somatic missense mutations in UBA1.2020 October 27, David B. Beck, Marcela A. Ferrada, Keith A. Sikora, Amanda K. Ombrello, et alia, “Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease”, in New England Journal...
    • Additionally, patients with VEXAS suffer from a spectrum of hematologic problems, including macrocytic anemia, thrombocytopenia, thromboembolic disease, and progressive bone marrow failure, which can evolve to hematologic malignancy2021 July 1, Peter C. Grayson, Bhavisha A. Patel, Neal S. Young, “VEXAS syndrome”, in Blood, volume 137, number 26, →DOI, page 3591

Origin of VEXAS

Acronym of vacuoles, E1 enzyme, X chromosome, autoinflammatory, somatic, after the core features of the disorder. First discovered in October 2020, with the report from The New England Journal of Medicine and identified by a multidisciplinary team of scientists (see quotations below).

Questions about VEXAS

What does VEXAS mean?
VEXAS means an autoimmune disease that causes inflammation in the body and mostly affects men.
What part of speech is VEXAS?
VEXAS is a noun.

Words near VEXAS in the dictionary

  1. vew
  2. vews
  3. vewy
  4. vex
  5. vexable
  6. VEXAS
  7. VEXAS syndrome
  8. vexata quaestio
  9. vexation
  10. vexations
  11. vexatious

Source and license

Adapted from Wiktionary: VEXAS (page history and authors). Text available under the Creative Commons Attribution-ShareAlike 4.0 license. Word.ws reformatted the entry and added links. Wiktionary data of 2026-09-02.

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